Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate

Nucl Med Biol. 1997 Apr;24(3):255-61. doi: 10.1016/s0969-8051(97)00060-7.


A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / chemistry*
  • Antibodies, Monoclonal / pharmacokinetics
  • Astatine / pharmacokinetics*
  • Glioma / diagnostic imaging*
  • Half-Life
  • Humans
  • Injections, Intravenous
  • Injections, Spinal
  • Iodine Radioisotopes
  • Mice
  • Neoplasm Transplantation
  • Radiation Dosage
  • Radionuclide Imaging
  • Radiopharmaceuticals / administration & dosage
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / pharmacokinetics
  • Tissue Distribution
  • Transplantation, Heterologous


  • Antibodies, Monoclonal
  • Iodine Radioisotopes
  • Radiopharmaceuticals
  • Astatine