Sox genes find their feet

Curr Opin Genet Dev. 1997 Jun;7(3):338-44. doi: 10.1016/s0959-437x(97)80147-5.


The identification of the mammalian testis-determining factor, SRY, led to the description of a new class of genes encoding transcription factors, the SOX gene family. SOX proteins display properties of both classical transcription factors and architectural components of chromatin. The dynamic and diverse patterns of expression of SOX genes and analysis of mutations in humans, mice and Drosophila suggest that SOX factors play key roles in decisions of cell fate during diverse developmental processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • DNA-Binding Proteins / genetics*
  • Developmental Biology
  • Gene Expression
  • High Mobility Group Proteins / genetics*
  • Humans
  • Molecular Biology*
  • Multigene Family / genetics
  • Mutation
  • Nuclear Proteins / genetics*
  • Sequence Homology
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • High Mobility Group Proteins
  • Nuclear Proteins
  • Transcription Factors