RNA-binding Proteins as Regulators of Gene Expression

Curr Opin Genet Dev. 1997 Jun;7(3):345-53. doi: 10.1016/s0959-437x(97)80148-7.


A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway of genetic information expression in eukaryotes. These processes are specified by cis-acting signals on RNAs and are mediated by specific trans-acting factors, including RNA-binding proteins and small complementary RNAs. Recent information has begun to define the molecular mechanisms by which RNA-binding proteins recognize specific RNA sequences and influence the processing and function of RNA molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation / genetics*
  • Humans
  • Protein Conformation
  • RNA / physiology
  • RNA-Binding Proteins / genetics*
  • Signal Transduction / genetics


  • RNA-Binding Proteins
  • RNA