Abstract
Serine/threonine receptors transduce signals for the TGF-beta family, several members of which, such as decapentaplegic and bone morphogenetic proteins, are involved in early patterning of the embryo. The gene encoding the anti-Müllerian hormone (AMH) receptor has recently been cloned; gene targeting produces the same effects as targeting of the AMH gene itself. Another divergent member of the TGF-beta family, GDNF, signals through Ret, a tyrosine kinase receptor; binding to Ret requires the cooperation of GDNFR-alpha. The signal transduction pathway of serine/threonine receptors is now being intensively studied; the immunophilin FKBP-12 and MAD proteins are known to be involved.
MeSH terms
-
Animals
-
Bone Morphogenetic Protein 15
-
Bone Morphogenetic Proteins / metabolism
-
Glial Cell Line-Derived Neurotrophic Factor
-
Growth Differentiation Factor 9
-
Growth Substances / metabolism
-
Humans
-
Inhibins / metabolism
-
Intercellular Signaling Peptides and Proteins*
-
Ligands
-
Nerve Growth Factors / metabolism
-
Nerve Tissue Proteins / metabolism
-
Protein Serine-Threonine Kinases / physiology*
-
Receptors, Growth Factor / physiology*
-
Receptors, Transforming Growth Factor beta*
-
Signal Transduction*
-
Transforming Growth Factor beta / metabolism
Substances
-
BMP15 protein, human
-
Bone Morphogenetic Protein 15
-
Bone Morphogenetic Proteins
-
GDF9 protein, human
-
GDNF protein, human
-
Glial Cell Line-Derived Neurotrophic Factor
-
Growth Differentiation Factor 9
-
Growth Substances
-
Intercellular Signaling Peptides and Proteins
-
Ligands
-
Nerve Growth Factors
-
Nerve Tissue Proteins
-
Receptors, Growth Factor
-
Receptors, Transforming Growth Factor beta
-
Transforming Growth Factor beta
-
Inhibins
-
Protein Serine-Threonine Kinases