Serine/threonine kinase receptors and ligands

Curr Opin Genet Dev. 1997 Jun;7(3):371-7. doi: 10.1016/s0959-437x(97)80151-7.

Abstract

Serine/threonine receptors transduce signals for the TGF-beta family, several members of which, such as decapentaplegic and bone morphogenetic proteins, are involved in early patterning of the embryo. The gene encoding the anti-Müllerian hormone (AMH) receptor has recently been cloned; gene targeting produces the same effects as targeting of the AMH gene itself. Another divergent member of the TGF-beta family, GDNF, signals through Ret, a tyrosine kinase receptor; binding to Ret requires the cooperation of GDNFR-alpha. The signal transduction pathway of serine/threonine receptors is now being intensively studied; the immunophilin FKBP-12 and MAD proteins are known to be involved.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 15
  • Bone Morphogenetic Proteins / metabolism
  • Glial Cell Line-Derived Neurotrophic Factor
  • Growth Differentiation Factor 9
  • Growth Substances / metabolism
  • Humans
  • Inhibins / metabolism
  • Intercellular Signaling Peptides and Proteins*
  • Ligands
  • Nerve Growth Factors / metabolism
  • Nerve Tissue Proteins / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Receptors, Growth Factor / physiology*
  • Receptors, Transforming Growth Factor beta*
  • Signal Transduction*
  • Transforming Growth Factor beta / metabolism

Substances

  • BMP15 protein, human
  • Bone Morphogenetic Protein 15
  • Bone Morphogenetic Proteins
  • GDF9 protein, human
  • GDNF protein, human
  • Glial Cell Line-Derived Neurotrophic Factor
  • Growth Differentiation Factor 9
  • Growth Substances
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Receptors, Growth Factor
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta
  • Inhibins
  • Protein-Serine-Threonine Kinases