The plakin family: versatile organizers of cytoskeletal architecture

Curr Opin Genet Dev. 1997 Jun;7(3):392-7. doi: 10.1016/s0959-437x(97)80154-2.

Abstract

Desmoplakin, plectin, bullous pemphigoid antigen 1 and envoplakin are four sequence-related proteins--recently named the plakin family--that localize to intermediate filaments and filament attachment sites at the plasma membrane. New interest in the plakins has been stimulated by the discoveries that they can link different cytoskeletal elements together and that loss of plakin function can cause diseases of the skin and other tissues.

Publication types

  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Autoantigens / genetics
  • Autoantigens / physiology
  • Carrier Proteins*
  • Collagen*
  • Cytoskeletal Proteins* / genetics
  • Cytoskeletal Proteins* / physiology
  • Desmoplakins
  • Dystonin
  • Humans
  • Intermediate Filament Proteins / genetics
  • Intermediate Filament Proteins / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Nerve Tissue Proteins*
  • Non-Fibrillar Collagens*
  • Plectin
  • Protein Conformation
  • Protein Precursors / genetics
  • Protein Precursors / physiology
  • Skin Diseases / genetics*

Substances

  • Autoantigens
  • Carrier Proteins
  • Cytoskeletal Proteins
  • DSP protein, human
  • DST protein, human
  • Desmoplakins
  • Dystonin
  • Intermediate Filament Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Non-Fibrillar Collagens
  • PLEC protein, human
  • Plectin
  • Protein Precursors
  • collagen type XVII
  • envoplakin
  • Collagen