NSAIDs, gastrointestinal injury, and cytoprotection

J M Scheiman

doi:10.1016/s0889-8553(05)70247-8

NSAIDs, gastrointestinal injury, and cytoprotection

Gastroenterol Clin North Am. 1996 Jun;25(2):279-98. doi: 10.1016/s0889-8553(05)70247-8.

Author

J M Scheiman¹

Affiliation

¹ Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, USA.

PMID: 9229573
DOI: 10.1016/s0889-8553(05)70247-8

Abstract

Gastrointestinal toxicity caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is the most frequent drug side effect in the United States. NSAIDs are implicated in the development of complicated peptic ulcer disease and injury to the small bowel and colon. NSAIDs interfere with prostaglandin-mediated epithelial defense mechanisms and also cause direct epithelial toxicity. Current and future approaches to the prevention and management of NSAID injury are reviewed.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / economics
Cost-Benefit Analysis
Digestive System / drug effects*
Digestive System / metabolism
Epithelium / drug effects
Epithelium / metabolism
Gastrointestinal Diseases / chemically induced
Gastrointestinal Diseases / metabolism
Gastrointestinal Diseases / prevention & control*
Humans
Mucous Membrane / drug effects
Mucous Membrane / metabolism
Prostaglandins / economics
Prostaglandins / therapeutic use
Risk Factors

Substances

Anti-Inflammatory Agents, Non-Steroidal
Prostaglandins