The significance of physical activity and some anthropometric parameters (body mass, body height, body mass index) in breast cancer genesis was examined in the study. Anamnestic study included 106 women with breast cancer and 106 hospital controls, age-matched (+/-3 years). The data about risk factors for breast cancer genesis were collected by the targeted epidemiological questionnaire. The basic statistic parameters (mean, standard error) and t-test were calculated. The results indicated that physical activity and body height higher values appeared to be protective, while body mass and body mass index higher values could be considered as risk factors for breast cancer.