Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

Cell. 1997 Jul 11;90(1):169-80. doi: 10.1016/s0092-8674(00)80323-2.

Abstract

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chick Embryo
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / physiology*
  • Embryonic Induction*
  • Eye Proteins
  • Hedgehog Proteins
  • Homeodomain Proteins / biosynthesis
  • Interneurons / classification
  • Interneurons / cytology
  • Interneurons / physiology
  • Motor Neurons / classification
  • Motor Neurons / cytology
  • Motor Neurons / physiology
  • Nervous System / cytology
  • Nervous System / embryology*
  • Neurons / cytology
  • Neurons / physiology*
  • Organ Culture Techniques
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Proteins / physiology*
  • Repressor Proteins
  • Rhombencephalon / cytology
  • Rhombencephalon / embryology
  • Signal Transduction
  • Spinal Cord / cytology
  • Spinal Cord / embryology
  • Stem Cells / cytology*
  • Stem Cells / physiology*
  • Trans-Activators*
  • Transcription Factors / biosynthesis
  • Transcription Factors / physiology*
  • Zebrafish Proteins

Substances

  • DNA-Binding Proteins
  • Eye Proteins
  • Hedgehog Proteins
  • Homeodomain Proteins
  • Nkx2.2 protein
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Proteins
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • Zebrafish Proteins