Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 388 (6639), 300-4

X-linked IAP Is a Direct Inhibitor of Cell-Death Proteases

Affiliations

X-linked IAP Is a Direct Inhibitor of Cell-Death Proteases

Q L Deveraux et al. Nature.

Abstract

The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to humans. Ectopic expression of human IAP proteins can suppress cell death induced by a variety of stimuli, but the mechanism of this inhibition was previously unknown. Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. As the caspases are highly conserved throughout the animal kingdom and are the principal effectors of apoptosis, our findings suggest how IAPs might inhibit cell death, providing evidence for a mechanism of action for these mammalian cell-death suppressors.

Similar articles

See all similar articles

Cited by 466 articles

See all "Cited by" articles

MeSH terms

Associated data

LinkOut - more resources

Feedback