Some properties of the hazard function of the two-mutation clonal expansion model

Risk Anal. 1997 Jun;17(3):391-9. doi: 10.1111/j.1539-6924.1997.tb00878.x.

Abstract

We discuss the hazard function of the two-mutation clonal expansion model with time-dependent parameters, with particular emphasis on identifiability of the parameters. We explicitly construct identifiable parameter combinations, and illustrate the properties of the hazard function under perturbations of the underlying biological parameters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cocarcinogenesis*
  • Humans
  • Mathematics
  • Models, Biological*
  • Mutation*
  • Proportional Hazards Models
  • Risk