A randomized controlled trial of penicillin vs clindamycin for the treatment of aspiration pneumonia in children

Arch Pediatr Adolesc Med. 1997 Jul;151(7):701-4. doi: 10.1001/archpedi.1997.02170440063011.


Objective: To compare the effectiveness of intravenous penicillin vs clindamycin for the treatment of aspiration pneumonia.

Design: A double-blind, randomized controlled trial.

Setting: A tertiary care pediatric hospital.

Patients: We enrolled 42 children, aged 6 months to 18 years, who were admitted to the hospital for the treatment of aspiration pneumonia. All of the children had underlying conditions that predispose to aspiration.

Intervention: The patients were randomly assigned to receive intravenous penicillin G sodium, 250,000 U/kg every 24 hours, or intravenous clindamycin phosphate, 30 mg/kg every 24 hours.

Main outcome measure: The primary outcome measure was "time to ready for discharge" from the hospital.

Results: In an effectiveness (intention to treat) analysis, the median time (interquartile range) to ready for discharge from the hospital was 4.9 days (range, 2.8-6.5 days) in the penicillin-treated group and 3.4 days (range, 2.3-6.8 days) in the clindamycin-treated group (P = .66). Results were not markedly altered when adjusted for the age difference of the groups or in the efficacy analysis (after the exclusion of 9 patients who withdrew from the trial). Rates for readmission to the hospital were similar in the 2 groups.

Conclusion: Penicillin and clindamycin seem to be equally effective for the treatment of aspiration pneumonia in children hospitalized for this illness.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Clindamycin / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Infant
  • Male
  • Penicillin G / therapeutic use*
  • Penicillins / therapeutic use*
  • Pneumonia, Aspiration / drug therapy*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Penicillins
  • Clindamycin
  • Penicillin G