Pathogenesis of Tourette's syndrome

J Child Psychol Psychiatry. 1997 Jan;38(1):119-42. doi: 10.1111/j.1469-7610.1997.tb01508.x.


This review presents a models of disease pathogenesis in the context of CNS development. It begins with an exploration of the clinical features and natural history of Tourette's syndrome. This is followed by a consideration of the role of genetic and nongenetic factors. An effort is then made to review the anatomical organization of the basal ganglia and related cortical sites. These circuits are intimately involved in the normal processing of sensorimotor, cognitive, and emotionally laden information. Evidence implicating these circuits in the pathobiology of Tourette's syndrome is then considered. The review closes with the prospects for advances in interdisciplinary research and therapeutics using this model as a guide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Basal Ganglia / physiopathology
  • Brain / physiopathology*
  • Brain Mapping
  • Cerebral Cortex / physiopathology
  • Child
  • Humans
  • Nerve Net / physiopathology
  • Neurotransmitter Agents / physiology*
  • Phenotype
  • Tourette Syndrome / genetics
  • Tourette Syndrome / physiopathology*


  • Neurotransmitter Agents