Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development

Mech Dev. 1997 Jun;64(1-2):53-9. doi: 10.1016/s0925-4773(97)00044-0.


cNkx2-8 represents a novel member of the NK2-family transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2-8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2-8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • Cloning, Molecular
  • DNA Primers / genetics
  • Digestive System / embryology*
  • Gene Expression Regulation, Developmental*
  • Genes, Homeobox*
  • Heart / embryology*
  • Homeodomain Proteins / genetics*
  • In Situ Hybridization
  • Multigene Family
  • Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Transcription Factors / genetics*


  • DNA Primers
  • Homeodomain Proteins
  • NKX2-8 protein, human
  • Transcription Factors