Calmodulin-regulated adenylyl cyclases and neuromodulation

Curr Opin Neurobiol. 1997 Jun;7(3):391-6. doi: 10.1016/s0959-4388(97)80068-2.


Coincidence detection and crosstalk between signal transduction systems play very important regulatory roles in the nervous system, particularly in the regulation of transcription. Coupling of the Ca2+ and cAMP regulatory systems by calmodulin-regulated adenylyl cyclases is hypothesized to be important for some forms of synaptic plasticity, neuroendocrine function, and olfactory detection. Recent studies of a mutant mouse deficient in type I calmodulin-sensitive adenylyl cyclase have provided the first evidence that adenylyl cyclases are important for synaptic plasticity, as well as for learning and memory in vertebrates.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenylyl Cyclases / drug effects*
  • Animals
  • Calmodulin / pharmacology*
  • Cyclic AMP / physiology*
  • Melatonin / metabolism
  • Mice
  • Signal Transduction / physiology
  • Smell / physiology


  • Calmodulin
  • Cyclic AMP
  • Adenylyl Cyclases
  • Melatonin