The InsP3 receptor and intracellular Ca2+ signaling

Curr Opin Neurobiol. 1997 Jun;7(3):339-45. doi: 10.1016/s0959-4388(97)80061-x.


The inositol 1,4,5-trisphosphate receptor (InsP3R) is a ligand-gated Ca2+-release channel on intracellular Ca2+ store sites (such as the endoplasmic reticulum), and plays an important role in intracellular Ca2+ signaling in a wide variety of cell types. Recent studies have shown that binding of inositol 1,4,5-trisphosphate (InsP3) to InsP3R isoforms is differentially regulated by Ca2+, and that InsP3R functions are finely regulated by phosphorylation via tyrosine kinases and protein kinase C, by dephosphorylation via calcineurin, and by binding to FKBP (FK506-binding protein). In addition, transient receptor potential (TRP) and TRP-like proteins appear to couple conformationally with the InsP3R for capacitative Ca2+ entry. The importance of InsP3R signaling in neuronal function has been demonstrated by gene targeting in mice and by studies of T-cell receptor signaling, apoptosis, meiotic maturation, and cytokinesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites / drug effects
  • Calcium / physiology*
  • Inositol 1,4,5-Trisphosphate / pharmacology
  • Inositol 1,4,5-Trisphosphate / physiology*
  • Mice
  • Signal Transduction / physiology*


  • Inositol 1,4,5-Trisphosphate
  • Calcium