Ca2+-dependent regulation in neuronal gene expression

Curr Opin Neurobiol. 1997 Jun;7(3):419-29. doi: 10.1016/s0959-4388(97)80072-4.


Ca2+ is an important signal-transduction molecule that plays a role in many intracellular signaling pathways. Recent advances have indicated that in neurons, Ca2+-controlled signaling mechanisms cooperate in order to discriminate amongst incoming cellular inputs. Ca2+-dependent transcriptional events can thereby be made selectively responsive to bursts of synaptic activity of specific intensity or duration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Gene Expression / genetics*
  • Hippocampus / metabolism*
  • Neurons / metabolism*
  • Neurons / physiology
  • Signal Transduction / physiology


  • Calcium