An unusual axonal polyneuropathy induced by low-dose interferon alfa-2a

Arch Neurol. 1997 Jul;54(7):907-8. doi: 10.1001/archneur.1997.00550190093020.


Objectives: To describe a patient who developed an unusual polyneuropathy after treatment with interferon alfa-2a for hepatitis C and to discuss issues related to diagnosis and pathogenesis.

Design: Case report.

Setting: Tertiary care center.

Case: A 46-year-old man with chronic hepatitis C had acute onset of an axonal polyneuropathy with prominent small-fiber involvement shortly after completing a standard 6-month course of therapy with low-dose interferon alfa-2a.

Main outcome and results: Further interferon treatment for hepatitis C was discontinued.

Conclusion: Standard, low-dose interferon alfa-2a treatment can produce a persistent predominantly small-fiber polyneuropathy.

Publication types

  • Case Reports

MeSH terms

  • Axons / drug effects
  • Electrophysiology
  • Hepatitis C / drug therapy
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / adverse effects*
  • Male
  • Middle Aged
  • Motor Neuron Disease / chemically induced*
  • Recombinant Proteins
  • Skin / drug effects
  • Skin / physiopathology


  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins