Selenite nuclear cataract: review of the model

Mol Vis. 1997 Jul 23;3:8.

Abstract

Selenite overdose cataract, an experimental model of nuclear cataract produced in young rats is reviewed. Topics include procedures for cataract production and assessment, metabolic and molecular changes in the epithelium of the lens, calcium accumulation, activation of calcium-activated protease system, mechanisms for crystallin precipitation, anti-cataract drug testing and relevance to human cataract.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium-Binding Proteins / genetics
  • Calpain / antagonists & inhibitors
  • Calpain / genetics
  • Calpain / physiology
  • Cataract / chemically induced
  • Cataract / drug therapy
  • Cataract / metabolism*
  • Chemical Precipitation
  • Crystallins / metabolism
  • Cysteine Proteinase Inhibitors / genetics
  • Cytoskeletal Proteins / drug effects
  • Cytoskeletal Proteins / metabolism
  • Disease Models, Animal*
  • Drug Evaluation, Preclinical
  • Epithelium / metabolism
  • Forecasting
  • Lens, Crystalline / metabolism*
  • RNA, Messenger / analysis
  • Rats
  • Sodium Selenite*

Substances

  • Calcium-Binding Proteins
  • Crystallins
  • Cysteine Proteinase Inhibitors
  • Cytoskeletal Proteins
  • RNA, Messenger
  • calpastatin
  • Calpain
  • Sodium Selenite
  • Calcium