Meta-analysis of best-evidence synthesis?

J Eval Clin Pract. 1995 Sep;1(1):29-36. doi: 10.1111/j.1365-2753.1995.tb00005.x.


This article examines the usefulness of meta-analysis, and articulates many of the criticisms that have been made of its workings. An attempt is made to outline the precautions that have to be taken before a scientifically useful and meaningful meta-analysis can be carried out. The problems encountered include heterogeneity of samples, conditions, interventions and end-points; narrow focus; curvilinearity of regression; lack of independence of determinants; synergistic interactions; contradictory experimental results. It is suggested that best-evidence synthesis, or theory-directed analysis, might be a safer option.

Publication types

  • Review

MeSH terms

  • Bias
  • Data Collection / standards
  • Data Interpretation, Statistical
  • Evidence-Based Medicine / methods*
  • Evidence-Based Medicine / standards
  • Humans
  • Meta-Analysis as Topic*
  • Regression Analysis
  • Reproducibility of Results