[Syncope with long QT interval in a 39 day-old infant treated with cisapride]

Arch Pediatr. 1997 Jun;4(6):535-7. doi: 10.1016/s0929-693x(97)87572-0.
[Article in French]


Cardiotoxicity of cisapride may increase when this drug is associated with ranitidine.

Case report: A 37-day old term infant, treated with cisapride (1.2 mg/kg/d) and ranitidine for regurgitations, was hospitalized for malaise. A prolonged QT interval (with isolate ventricular extrasystoles), noted at admission, disappeared rapidly after cisapride withdrawal. Linkage to cisapride was probable, promoted by high dosage and cisapride metabolism inhibition by ranitidine, but its plasma concentration was not measured.

Conclusion: This case report stresses the problem of cisapride dosage in infants and the question of an interaction between cisapride and ranitidine.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anti-Ulcer Agents / adverse effects*
  • Anti-Ulcer Agents / therapeutic use
  • Cisapride
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Gastroesophageal Reflux / drug therapy
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Infant
  • Long QT Syndrome / chemically induced*
  • Long QT Syndrome / complications
  • Male
  • Piperidines / adverse effects*
  • Piperidines / therapeutic use
  • Ranitidine / therapeutic use
  • Syncope / chemically induced*
  • Syncope / complications


  • Anti-Ulcer Agents
  • Histamine H2 Antagonists
  • Piperidines
  • Ranitidine
  • Cisapride