Bilateral xanthine nephrolithiasis in a dog

J Small Anim Pract. 1997 Jul;38(7):302-5. doi: 10.1111/j.1748-5827.1997.tb03471.x.


Xanthinuria is an uncommon metabolic disorder clinically manifested as urolithiasis. There are two forms of the disease, congenital and iatrogenic. The former was diagnosed in a four-year-old dachshund bitch. The patient was presented with signs of terminal chronic renal failure. Urine was bacteriologically sterile with massive amorphous crystalluria. Bilateral nephrolithiasis was diagnosed at necropsy. The kidneys were shrunken with marked atrophy of the renal cortex and medulla. Infrared spectrometry revealed that the stones comprised 100 per cent xanthine. Later, two of the patient's siblings were examined for urine xanthine content; both showed higher concentrations of xanthine than a control dog. The described case is compared with seven known published cases of congenital xanthinuria.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Crystallization
  • Dog Diseases / congenital
  • Dog Diseases / diagnosis*
  • Dog Diseases / urine
  • Dogs
  • Female
  • Kidney Calculi / chemistry*
  • Kidney Calculi / pathology
  • Kidney Calculi / urine
  • Kidney Cortex / pathology
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / veterinary
  • Kidney Medulla / pathology
  • Spectrophotometry, Infrared / methods
  • Spectrophotometry, Infrared / veterinary
  • Xanthine
  • Xanthines / analysis*
  • Xanthines / urine


  • Xanthines
  • Xanthine