Abstract
Frzb-1 is a secreted factor that was recently shown to inhibit signaling by Wnts 1 and 8. Frzb-1 contains an amino terminal domain that is homologous to the Drosophila polarity gene frizzled; several other secreted proteins that share this feature have now been identified. These findings raise the question of whether or not Frzb-1 is a general inhibitor of signaling by all Wnts. We show that signaling of Wnts -3A, 5A, and 11 is not blocked by Frzb-1, demonstrating that Frzb-1 can discriminate both between the principle functional Wnt classes that have been proposed and within them.
MeSH terms
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Animals
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Glycoproteins / physiology*
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Intracellular Signaling Peptides and Proteins
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Proteins / physiology*
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Proto-Oncogene Proteins / physiology*
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Signal Transduction
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Wnt Proteins
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Wnt-5a Protein
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Wnt1 Protein
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Wnt3 Protein
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Xenopus Proteins
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Xenopus laevis
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Zebrafish Proteins*
Substances
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Glycoproteins
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Intracellular Signaling Peptides and Proteins
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Proteins
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Proto-Oncogene Proteins
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WD repeat containing planar cell polarity effector
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WNT1 protein, Xenopus
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WNT5A protein, human
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Wnt Proteins
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Wnt-5a Protein
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Wnt1 Protein
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Wnt3 Protein
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Xenopus Proteins
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Zebrafish Proteins
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wnt11b protein, Xenopus
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wnt8a protein, Xenopus