Modular peptide recognition domains in eukaryotic signaling

Annu Rev Biophys Biomol Struct. 1997;26:259-88. doi: 10.1146/annurev.biophys.26.1.259.


A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / metabolism*
  • Phosphoprotein Phosphatases / chemistry*
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / chemistry*
  • Signal Transduction / physiology*
  • src Homology Domains*


  • Peptides
  • Protein-Tyrosine Kinases
  • Phosphoprotein Phosphatases