Auditory event-related potentials and statistical probability mapping in obsessive-compulsive disorder

Clin Electroencephalogr. 1997 Jul;28(3):148-54. doi: 10.1177/155005949702800306.

Abstract

The current exploratory investigation was undertaken to replicate and extend previous findings of auditory event related potentials (ERPs) observed in obsessive-compulsive disorder (OCD). Similar to previous ERP studies, this study revealed a decreased slow wave (SW) (post P300) latency, a trend towards decreased P300 latency and a greater N200 amplitude in OCD subjects than in controls. In addition, the chronicity of OCD symptoms was correlated with the 140-170 millisecond integrated amplitude and the severity of OCD symptoms correlated with the 386-438 millisecond integrated amplitude. Current findings lend additional support to evidence suggesting OCD represents, in part, hyperarousal of the cortex.

MeSH terms

  • Adult
  • Arousal / physiology
  • Brain Mapping*
  • Cerebral Cortex / physiopathology
  • Dominance, Cerebral / physiology
  • Electroencephalography / statistics & numerical data*
  • Event-Related Potentials, P300 / physiology
  • Evoked Potentials, Auditory / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / diagnosis
  • Obsessive-Compulsive Disorder / physiopathology*
  • Probability
  • Reaction Time / physiology
  • Reference Values