MHC class II B genes in the channel catfish (Ictalurus punctatus)

Dev Comp Immunol. Jan-Feb 1997;21(1):13-23. doi: 10.1016/s0145-305x(97)00003-7.


Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus. The inferred amino acid sequences show strong evidence for a functional polypeptide chain with a peptide binding region. Southern blot analysis reveals polymorphism in the MHC class II B gene(s) of the channel catfish and suggests the presence of two to four genes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Genes, MHC Class II / genetics*
  • Ictaluridae / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Associated data

  • GENBANK/U77597
  • GENBANK/U77598