To understand the long term impact of the disposal of radioactive waste on the Kara Sea, partition coefficients (Kd) for several important radionuclides, the mineralogy of the sediment, and the relationship of Kd to liquid-to-solid ratio were quantified. Sediment was obtained from four locations in the Kara Sea area. Slow sorption kinetics were observed for 85Sr, 232U, 125I and 99Tc, whilst sorption was rapid (less than 50 h to steady-state) for 137Cs, 210Pb, and 241Am. Partition coefficients (Kd) were determined using batch type experiments and sorption isotherms which were developed for 85Sr, 99Tc, 125I, U and 137Cs. Partition coefficients for 137Cs were approx. 350 ml/g for sediment from the Trough and 180 ml/g for Stepovogo Fjord. This difference may be caused by the lower fraction of expandable clay in sediment from the fjord. Uptake of 85Sr, 99Tc, 125I, and U were all similar for both locations, with Kd values averaging 4, 3, 17 and 60 ml/g, respectively. The Kd for 137 Cs varied non-linearly from 40 to 3800 ml/g as the liquid-to-solid ratio varied from 3.4 to 6500, but only when the sorption capacity was high compared to the mass of 137Cs in the closed system of the experiment. Under identical conditions, sediment with lower Kd values showed no effect. Oxidation of sediment effectively desorbed 99Tc from the solid phase, whilst it caused increased uptake of 85Sr and U. In sequential rinses with fresh seawater, desorption was limited to 60% of 137Cs and 85Sr, and 35% of uranium.