Localization of tissue inhibitor of metalloproteinases-3 in neurodegenerative retinal disease

Neuroreport. 1997 Jul 7;8(9-10):2169-72. doi: 10.1097/00001756-199707070-00015.


Tissue inhibitor of metalloproteinases-3 (TIMP-3) is one of a family of genes whose products are implicated in the regulation of remodelling of the extracellular matrix. The level of mRNA coding for TIMP-3 is increased in retinas affected by the photoreceptor degenerative disease, simplex retinitis pigmentosa (RP), and mutations in TIMP-3 are associated with an inherited form of macular dystrophy. Here we compare TIMP-3 protein expression in normal retina and in those affected by RP and by age-related macular degeneration. Immunoreactive TIMP-3 is present in normal retinal pigment epithelium, and in degenerative retinas particularly at Bruch's membrane and additionally in photoreceptor-retaining regions in simplex RP. The pattern suggests a role for TIMP-3 in normal retinal homeostasis, and, in the disease state, in the modulation of extracellular matrix metabolism and neovascularization.

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • Humans
  • Immunohistochemistry
  • Male
  • Protease Inhibitors / metabolism*
  • Proteins / metabolism*
  • Retinal Degeneration / metabolism*
  • Tissue Inhibitor of Metalloproteinase-3


  • Antibodies, Monoclonal
  • Protease Inhibitors
  • Proteins
  • Tissue Inhibitor of Metalloproteinase-3