Association of the TNFa2 microsatellite allele with the presence of colorectal cancer

G Gallagher; M Lindemann; H H Oh; S Ferencik; M K Walz; A Schmitz; S Richards; J Eskdale; M Field; H Grosse-Wilde

doi:10.1111/j.1399-0039.1997.tb02833.x

Association of the TNFa2 microsatellite allele with the presence of colorectal cancer

Tissue Antigens. 1997 Jul;50(1):47-51. doi: 10.1111/j.1399-0039.1997.tb02833.x.

Authors

G Gallagher¹, M Lindemann, H H Oh, S Ferencik, M K Walz, A Schmitz, S Richards, J Eskdale, M Field, H Grosse-Wilde

Affiliation

¹ Department of Surgery, University of Glasgow, United Kingdom.

PMID: 9243755
DOI: 10.1111/j.1399-0039.1997.tb02833.x

Abstract

Independently, our two groups collaborating in this report performed association studies to consider the influence of the TNF region within the human MHC on the presence of colorectal cancer. In the Glasgow Study, 84 colorectal cancer patients were compared with 91 controls at the TNFa microsatellite locus. Analysis of individual alleles by Fisher's exact test revealed a significant overrepresentation of the TNFa2 allele in the colorectal cancer group, after correcting for multiple comparisons. In the Essen Study, 47 colorectal cancer patients were compared with 117 matched controls, and the hypothesis of TNFa2 overrepresentation in colorectal cancer was confirmed. These data provide evidence for the involvement of the TNF locus in the pathogenetic etiology of colorectal cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Colorectal Neoplasms / genetics*
Humans
Microsatellite Repeats*
Tumor Necrosis Factor-alpha / genetics*

Substances

Tumor Necrosis Factor-alpha