The frequencies of the pC allele of red cell acid phosphatase (AcPI) and a group of mitochondrial DNA (mtDNA) types BamHI-3/MspI-4 were shown to have similar geographic distribution in Caucasoid populations of six regions of Europe and Asia. The maximum frequency values of these markers were revealed in southern and southeastern Europe. The possibility of associations between these variants of polymorphism in the genotype-mitotype system is discussed. The geographical gradients of pC and BamHI-3/MspI-4 correlate with the directions of neolithic migrations of Caucasoids from the Near East to Europe. The region of maximum frequency values of pC and BamHI-3/MspI-4 is supposed to be largely consistent with the area where considerable enhancing of the population size of neolithic migrants from the Near East and their mixing with the ancient population of Europe occurred.