CD8alphaalpha T cells in lesions of Listeria monocytogenes-infected beta2m-deficient mice

Microb Pathog. 1997 Aug;23(2):101-6. doi: 10.1006/mpat.1997.0133.

Abstract

The beta2-microglobulin (beta2m)-deficient mutant mice lack alphabeta TCR CD8alphabeta T cells. We found markedly impaired granuloma formation in Listeria monocytogenes-infected beta2m-/- mice. Abundant CD8alphaalpha T cells were identified in loosely structured infiltrative liver lesions. Microfluorescence analysis disclosed that these CD8alphaalpha T cells expressed mostly the gammadelta TCR. CD8alphaalpha T cells were also found in the spleen of Listeria-infected beta2m-/- mice. These data provide first evidence for CD8alphaalpha T cells in listerial lesions of beta2m-/- mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / immunology*
  • Female
  • Granuloma / pathology
  • Listeriosis / immunology*
  • Listeriosis / pathology
  • Liver / cytology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Antigen, T-Cell, gamma-delta / analysis
  • Spleen / cytology
  • beta 2-Microglobulin / deficiency*

Substances

  • Receptors, Antigen, T-Cell, gamma-delta
  • beta 2-Microglobulin