Abstract
Topical cyclosporin A (CsA) was compared with dexamethasone, indomethacin and phenidone in edema, increases in vascular permeability, eicosanoids and cell-influx induced by arachidonic acid (AA) and tetradecanoylphorbol acetate (TPA) in mouse ears. CsA ED(50) on AA-edema (7.7 micrograms/ear) was similar to dexamethasone and lower than indomethacin and phenidone. CsA ED(50) in TPA edema (21 micrograms/ear) was higher than dexamethasone and lower than indomethacin or phenidone. All drugs equally reduce the AA-induced increase in vascular permeability, but CsA and dexamethasone had more activity on TPA. AA-increase in vascular 6-keto-PGF1 alpha was reduced by dexamethasone, indomethacin and phenidone but not by CsA; only phenidone reduced LTB4. TPA-increase in 6-keto-PGF1 alpha was reduced by CsA and indomethacin while CsA, dexamethasone and phenidone decreased LTB4. CsA, indomethacin and phenidone, but not dexamethasone, suppressed AA-neutrophil influx. In TPA-ears all drugs produced similar reduction in neutrophil influx. CsA was shown to be a good topical anti-inflammatory drug.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylglucosaminidase / antagonists & inhibitors
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Administration, Topical
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Arachidonic Acid / toxicity
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Capillary Permeability / drug effects
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Cyclooxygenase Inhibitors / pharmacology
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Cyclosporine / administration & dosage*
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Dermatitis, Contact / drug therapy*
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Dermatitis, Contact / etiology
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Dermatitis, Contact / physiopathology
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Dexamethasone / pharmacology
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Eicosanoids / biosynthesis
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Glucocorticoids / pharmacology
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Immunosuppressive Agents / administration & dosage*
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Indomethacin / pharmacology
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Lipoxygenase Inhibitors / pharmacology
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Male
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Mice
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Peroxidase / antagonists & inhibitors
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Pyrazoles / pharmacology
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Tetradecanoylphorbol Acetate / toxicity
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Eicosanoids
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Glucocorticoids
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Immunosuppressive Agents
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Lipoxygenase Inhibitors
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Pyrazoles
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Arachidonic Acid
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Dexamethasone
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Cyclosporine
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Peroxidase
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Acetylglucosaminidase
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phenidone
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Tetradecanoylphorbol Acetate
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Indomethacin