Epidermolysis bullosa simplex in the Collie dog

J Am Vet Med Assoc. 1977 Oct 15;171(8):721-7.


Epidermolysis bullosa simplex was diagnosed in 4 Collie dogs. Three of the dogs were less than 6 months old when lesions were first noticed. Lesions were characterized by alopecia, erythema, edema, erythematous plaques, erosions, ulcers, crusts, atrophy, pigmentary changes, and (rarely) blisters affecting the skin over bony prominences and joints of the limbs, face, lips, and ears. Minimal to moderate pruritus or pain was manifested by chewing and licking at the affected areas of the limbs and by pawing and rubbing at the face and ears. Lesions could be induced by frictional trauma in areas of normal skin. Diagnosis was confirmed by histologic examination of affected tissues and induced lesions. Therapy with large oral doses of prednisolone and avoidance of trauma were palliative.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dog Diseases* / drug therapy
  • Dog Diseases* / pathology
  • Dogs
  • Epidermolysis Bullosa / drug therapy
  • Epidermolysis Bullosa / pathology
  • Epidermolysis Bullosa / veterinary*
  • Female
  • Male
  • Prednisolone / therapeutic use
  • Skin / pathology


  • Prednisolone