In vitro activity of trimethoprim against Borrelia burgdorferi

Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):458-60. doi: 10.1007/BF02471911.


A new culture medium has been developed to evaluate the activity of trimethoprim and sulfamethoxazole against Borrelia burgdorferi in vitro. In this specially modified Barbour-Stoenner-Kelly medium, in which antagonizing substances were reduced to a minimum, trimethoprim was more active against Borrelia burgdorferi than against a sensitive strain of Escherichia coli, but sulfamethoxazole was not active against Borrelia burgdorferi.

MeSH terms

  • Anti-Bacterial Agents*
  • Anti-Infective Agents, Urinary / pharmacology*
  • Borrelia burgdorferi Group / drug effects*
  • Borrelia burgdorferi Group / physiology
  • Colony Count, Microbial
  • Culture Media / chemistry*
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination / pharmacology*
  • Escherichia coli / drug effects*
  • Escherichia coli / physiology
  • Microbial Sensitivity Tests
  • Sulfamethoxazole / pharmacology*
  • Trimethoprim / pharmacology*


  • Anti-Bacterial Agents
  • Anti-Infective Agents, Urinary
  • Culture Media
  • Trimethoprim
  • Sulfamethoxazole