The alpha v beta 3 integrin "vitronectin receptor"

Int J Biochem Cell Biol. 1997 May;29(5):721-5. doi: 10.1016/s1357-2725(96)00155-0.


The alpha v beta 3 "vitronectin receptor" is a member of the integrin superfamily of adhesion molecules. As such, this 160/85 kDa heterodimeric protein exhibits many of the typical structural and functional features of integrins. It mediates cell adhesion to extracellular matrix by recognizing the conserved arg-gly-asp (RGD) sequence of several plasma and matrix proteins. Recently, it has also been shown that alpha v beta 3 is involved in signal transduction and cell to cell interactions. alpha v beta 3 is highly expressed in bone resorbing cells, osteoclasts, and upregulated in response to vascular damage, during angiogenesis and in certain types of malignancy. Antagonists of alpha v beta 3 are being developed for use in a variety of diseases associated with altered receptor function or level.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Molecular
  • Mutagenesis, Site-Directed
  • Receptors, Vitronectin / chemistry
  • Receptors, Vitronectin / genetics
  • Receptors, Vitronectin / physiology*


  • Receptors, Vitronectin