[A risk of pulmonary edema associated with G-CSF pretreatment]

Masui. 1997 Jul;46(7):946-50.
[Article in Japanese]


We reported a case of severe pulmonary edema in the normal adult after bone marrow harvesting (BMH), who had received granular cell stimulating factor (G-CSF) pretreatment. The patient was 38 year old healthy man who was a donor to his son suffering from SCID (severe complicated immunodefficiency). He was administered total of G-CSF 750 mcg for three days before BMH. At the end of the BMH procedure, the patient was becoming dyspneic followed by severe pulmonary edema that continued about 8 hours. The levels of TNF alpha and IL-6 in his plasma and endotracheal exudate were abnormally as high as 10 and 130 pg.ml-1 of TNF alpha in plasma and exudate respectively and as 51.8 pg.ml-1 of IL-6 in plasma. We speculate that G-CSF activates white cells and induces leaking of cytokines from white cells, and the severity of pulmonary edema is associated with the cytokines.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Anesthesia, General
  • Bone Marrow Transplantation
  • Granulocyte Colony-Stimulating Factor / administration & dosage
  • Granulocyte Colony-Stimulating Factor / adverse effects*
  • Humans
  • Interleukin-6 / metabolism
  • Leukocytes / metabolism
  • Male
  • Premedication
  • Pulmonary Edema / etiology*
  • Tissue Donors*
  • Tumor Necrosis Factor-alpha / metabolism


  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Granulocyte Colony-Stimulating Factor