The complete genome sequence of the gastric pathogen Helicobacter pylori

Nature. 1997 Aug 7;388(6642):539-47. doi: 10.1038/41483.


Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigenic Variation
  • Bacterial Adhesion
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Biological Evolution
  • Cell Division
  • DNA Repair
  • DNA, Bacterial / genetics
  • Gene Expression Regulation, Bacterial
  • Genome, Bacterial*
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / metabolism
  • Helicobacter pylori / pathogenicity
  • Hydrogen-Ion Concentration
  • Molecular Sequence Data
  • Protein Biosynthesis
  • Recombination, Genetic
  • Transcription, Genetic
  • Virulence


  • Bacterial Proteins
  • DNA, Bacterial

Associated data

  • GENBANK/AE000523
  • GENBANK/AE000524
  • GENBANK/AE000525
  • GENBANK/AE000526
  • GENBANK/AE000527
  • GENBANK/AE000528
  • GENBANK/AE000529
  • GENBANK/AE000530
  • GENBANK/AE000531
  • GENBANK/AE000532
  • GENBANK/AE000533
  • GENBANK/AE000534
  • GENBANK/AE000535
  • GENBANK/AE000536
  • GENBANK/AE000537
  • GENBANK/AE000538
  • GENBANK/AE000539
  • GENBANK/AE000540
  • GENBANK/AE000541
  • GENBANK/AE000542
  • GENBANK/AE000543
  • GENBANK/AE000544
  • GENBANK/AE000545
  • GENBANK/AE000546
  • GENBANK/AE000547
  • GENBANK/AE000548
  • GENBANK/AE000549