The importance of plasma polymorphonuclear (PMN) elastase determination in patients with uveitis

Acta Ophthalmol Scand. 1997 Jun;75(3):287-9. doi: 10.1111/j.1600-0420.1997.tb00775.x.


Purpose: Polymorphonuclear elastase is used as an important marker for inflammatory disease. We wanted to show whether polymorphonuclear elastase could be a marker in uveitis.

Methods: Twenty-two patients with uveitis and 30 healthy control subjects were included in the study. Polymorphonuclear elastase levels were determined by immunoactivation method before and after periods of corticosteroid and/or cyclosporin treatments.

Results: The levels were high in all of the patients before treatment; the levels reached normal range with treatment. In some cases, however, uveitis could not be suppressed in spite of treatment; these patients had high polymorphonuclear elastase levels.

Conclusion: It was concluded that determination of polymorphonuclear elastase level may be used for monitoring of uveitis.

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / blood
  • Cyclosporine / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Leukocyte Count
  • Leukocyte Elastase / blood*
  • Male
  • Middle Aged
  • Treatment Outcome
  • Uveitis / blood*
  • Uveitis / drug therapy


  • Biomarkers
  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclosporine
  • Leukocyte Elastase