Alternative forms of the scavenger receptor BI (SR-BI)

J Lipid Res. 1997 Jul;38(7):1490-5.


The class B, type I scavenger receptor has been implicated as a receptor for high density lipoprotein (HDL). We have isolated a murine cDNA clone encoding an alternative form of SR-BI that differs in the putative cytoplasmic domain of the receptor. This variant form, likely the result of alternative mRNA splicing, is designated SR-BI.2. SR-BI.2 mRNA was detected in mouse tissues known to express SR-BI and tissue-specific differences in the relative abundance of SR-BI.2 were apparent. In mouse adrenal glands, SR-BI.2 represented approximately one-third of total SR-BI mRNA, whereas in mouse testes, SR-BI.2 represented the major mRNA species (79% of total). SR-BI.2 was also detected in the human cell lines examined, namely HeLa, HepG2, and THP-1 cells. CHO cells transfected with the mouse SR-BI.2 cDNA expressed significant levels of SR-BI.2 protein and acquired the ability to take up fluorescent lipid (DiI) from DiI-HDL. Alternative splicing of SR-BI represents a potentially important process for the regulation of SR-BI expression and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue / chemistry
  • Adrenal Glands / chemistry
  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • CD36 Antigens / chemistry
  • CD36 Antigens / genetics*
  • Cell Line
  • Genetic Variation*
  • Humans
  • Liver / chemistry
  • Male
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • Receptors, Immunologic*
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Testis / chemistry
  • Transfection


  • CD36 Antigens
  • Membrane Proteins
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • SCARB1 protein, human
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B