Guiding ribose methylation of rRNA

Trends Biochem Sci. 1997 Jul;22(7):257-61. doi: 10.1016/s0968-0004(97)01057-8.


Eukaryotic rRNAs contain a complex set of ribose-methylated nucleotides. Why are these nucleotides modified and how are they selected? A large family of small nucleolar RNAs (snoRNAs) with long complementarities to sites of rRNA methylation has been recently found to guide such modifications, opening up a direct approach to the study of their elusive function. Ribose methylation can also be targeted to non-rRNA sequences by tailored snoRNA guides, possibly providing a highly selective tool for altering gene expression at the post-transcriptional level.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • Binding Sites
  • Methylation
  • Models, Molecular
  • Nucleic Acid Conformation
  • RNA, Antisense
  • RNA, Ribosomal / chemistry
  • RNA, Ribosomal / metabolism*
  • Ribose / metabolism*


  • RNA, Antisense
  • RNA, Ribosomal
  • Ribose