Abstract
We compared 12 patients with obsessive-compulsive disorder (OCD) and six control subjects by 1H-magnetic resonance spectroscopy. Significantly lower relative N-acetyl-aspartate (NAA) levels were found in the right striatum of OCD patients, as well as a decrease of anterior cingulate NAA that correlated with severity of illness. Age and sex were correlated to striatal NAA levels.
MeSH terms
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Adult
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / analysis
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Cell Count
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Corpus Striatum / anatomy & histology*
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Corpus Striatum / chemistry
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Corpus Striatum / cytology
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Female
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Functional Laterality
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Gyrus Cinguli / anatomy & histology*
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Gyrus Cinguli / chemistry
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Gyrus Cinguli / cytology
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Humans
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Hydrogen
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Magnetic Resonance Spectroscopy*
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Male
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Obsessive-Compulsive Disorder / diagnosis*
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Obsessive-Compulsive Disorder / metabolism
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Parietal Lobe / anatomy & histology
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Parietal Lobe / chemistry
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Parietal Lobe / cytology
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Severity of Illness Index
Substances
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Aspartic Acid
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Hydrogen
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N-acetylaspartate