The vertebrate organizer: structure and molecules

Trends Genet. 1996 Dec;12(12):525-31. doi: 10.1016/s0168-9525(97)81401-1.

Abstract

Since the identification of the first organizer gene, goosecoid, more than 15 organizer-specific genes have been characterized. Here, we present our current understanding of the roles of these molecules in amphibians fish and amniotes and show how there identification has confirmed Spemann's original proposition that the vertebrate organizer is subdivided into separate domains: the head, trunk and tail organizers.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Embryonic Induction / genetics*
  • Fishes / genetics
  • Gene Expression
  • Gene Expression Regulation, Developmental*
  • Mice
  • Vertebrates / embryology
  • Vertebrates / genetics*
  • Xenopus