vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis

FEBS Lett. 1997 Jul 21;412(1):183-9. doi: 10.1016/s0014-5793(97)00775-8.


We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / genetics*
  • Cell Adhesion Molecules / genetics*
  • Gene Expression
  • Gene Expression Regulation*
  • Hippocampus / drug effects
  • Hippocampus / growth & development
  • Hippocampus / metabolism
  • Homer Scaffolding Proteins
  • Kainic Acid / pharmacology
  • Long-Term Potentiation*
  • Male
  • Microfilament Proteins
  • Molecular Sequence Data
  • Neuropeptides / genetics*
  • Phosphoproteins / genetics*
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Wistar
  • Seizures / metabolism*
  • Synapses / physiology*
  • Tissue Distribution


  • Carrier Proteins
  • Cell Adhesion Molecules
  • Homer Scaffolding Proteins
  • Microfilament Proteins
  • Neuropeptides
  • Phosphoproteins
  • RNA, Messenger
  • vasodilator-stimulated phosphoprotein
  • Kainic Acid

Associated data

  • GENBANK/AB003726