Complementary Value of Five Carcinoma Markers for the Diagnosis of Malignant Mesothelioma, Adenocarcinoma Metastasis, and Reactive Mesothelium in Serous Effusions

Diagn Cytopathol. 1997 Aug;17(2):115-20. doi: 10.1002/(sici)1097-0339(199708)17:2<115::aid-dc6>3.0.co;2-f.

Abstract

Cytological slides of serous fluids of 41 malignant mesotheliomas, 88 metastatic adenocarcinomas, and 25 reactive effusions were immunostained with the antibodies anti-CEA, MOC-31, Leu-M1, Ber-EP4, and B72.3. Most mesotheliomas and all reactive fluids failed to stain with these antibodies. The sensitivity of the five markers to detect carcinoma cells differed remarkably. Especially MOC-31, Ber-EP4, and B72.3 stained with a high number of carcinoma cases and the complemetary value of Ber-EP4 and B72.3 to immunostain carcinoma cells was impressive: 94% of the metastatic adenocarcinoma cases reacted with Ber-EP4 or B72.3 in contrast to 1 of 41 malignant mesotheliomas.

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / secondary
  • Antibodies, Monoclonal
  • Antibodies, Neoplasm*
  • Biomarkers, Tumor*
  • Humans
  • Immunohistochemistry
  • Mesothelioma / chemistry
  • Mesothelioma / diagnosis*
  • Mesothelioma / pathology
  • Peritoneal Neoplasms / chemistry
  • Peritoneal Neoplasms / diagnosis*
  • Peritoneal Neoplasms / pathology
  • Pleural Effusion / chemistry
  • Pleural Effusion / cytology*
  • Pleural Effusion / pathology
  • Pleural Neoplasms / chemistry
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / pathology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neoplasm
  • Biomarkers, Tumor