Olfactory identification in elderly schizophrenia and Alzheimer's disease

Neurobiol Aging. Mar-Apr 1997;18(2):163-7. doi: 10.1016/s0197-4580(97)00015-8.


In the present study we assessed olfactory identification ability using the University of Pennsylvania Smell Identification Test (UPSIT) in 16 elderly patients with schizophrenia (ES), 20 patients with a diagnosis of probable Alzheimer's disease (AD), and 20 healthy elderly controls (EC). Both patient groups exhibited marked deficits in UPSIT performance relative to controls. ES and AD patients with similar levels of general cognitive impairment did not differ on the UPSIT, suggesting that the two disorders may share a common dysfunction in olfactory brain regions. While there have been recent reports of greater olfactory impairment in males, neither patient group exhibited significant gender differences on the UPSIT.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / psychology*
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales
  • Schizophrenic Psychology*
  • Sex Characteristics
  • Smell / physiology*