Treatment of superficial bladder cancer with intravesical chemotherapy

Semin Surg Oncol. Sep-Oct 1997;13(5):335-41. doi: 10.1002/(sici)1098-2388(199709/10)13:5<335::aid-ssu7>3.0.co;2-e.

Abstract

Proper care of patients with superficial bladder cancer requires the assessment of multiple factors, including an understanding of the natural history of this disease, accurate clinical staging, and the expected efficacy of each drug. The pharmacology of intravesical mytomycin C is discussed in detail, as many of this drug's pharmacological principles are applicable to all intravesical chemotherapeutic agents, including doxorubicin, thiotepa, bacillus Calmette-Guérin, epirubicin, and ethoglucid. The bladder wall, bladder cavity, chemical properties of intravesical chemotherapeutic agents, and tumor considerations are discussed. Suggestions based on pharmacological studies are presented to optimize the efficacy of intravesical chemotherapy.

Publication types

  • Review

MeSH terms

  • Administration, Intravesical
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / therapeutic use
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / therapeutic use
  • Doxorubicin / administration & dosage
  • Doxorubicin / therapeutic use
  • Epirubicin / administration & dosage
  • Epirubicin / therapeutic use
  • Ethoglucid / administration & dosage
  • Ethoglucid / therapeutic use
  • Humans
  • Mitomycin / administration & dosage
  • Mitomycin / therapeutic use
  • Neoplasm Staging
  • Thiotepa / administration & dosage
  • Thiotepa / therapeutic use
  • Treatment Outcome
  • Urinary Bladder / drug effects
  • Urinary Bladder Neoplasms / drug therapy*
  • Urinary Bladder Neoplasms / pathology
  • Urinary Bladder Neoplasms / physiopathology
  • Urinary Bladder Neoplasms / therapy

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • BCG Vaccine
  • Epirubicin
  • Ethoglucid
  • Mitomycin
  • Doxorubicin
  • Thiotepa