Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis

Arthritis Rheum. 1997 Aug;40(8):1504-11. doi: 10.1002/art.1780400819.


Objective: To determine if antibodies to the collagen-like region of C1q (C1q-CLR) are present in the glomerular immune deposits of patients with systemic lupus erythematosus (SLE).

Methods: Kidney tissues were obtained at autopsy, glomeruli were isolated, and glomerular basement membrane fragments were prepared. Antibodies were extracted with low pH or with DNase.

Results: The concentrations of antibodies to C1q-CLR recovered from the glomeruli were > or =50-fold higher per unit of IgG than that found in the serum or in the serum and interstitial fluid entrained in glomeruli. Antibodies to C1q-CLR were recovered from glomeruli of 4 of 5 patients with proliferative glomerulonephritis at autopsy.

Conclusion: This is the first demonstration that antibodies to C1q-CLR are deposited and concentrated in the renal glomeruli of patients with SLE. These antibodies, thus, have the potential of contributing to the pathogenesis of lupus glomerulonephritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies / metabolism
  • Basement Membrane / immunology
  • Cadaver
  • Complement C1q / immunology*
  • Humans
  • Immunoglobulin G / analysis
  • Kidney Glomerulus / immunology*
  • Lupus Nephritis / immunology*


  • Antibodies
  • Immunoglobulin G
  • Complement C1q