Precautionary note for use of bisulfite in pharmaceutical formulations

J Pharm Sci. 1977 Dec;66(12):1775-6. doi: 10.1002/jps.2600661234.


The effect of sodium bisulfite on aspirin hydrolysis was studied at 40 degrees in the pH range of 6.5-7.5. Significant catalytic activity by the sulfite ion was observed. Second-order rate constants were calculated for this catalysis and compared to other buffer species. The sulfite ion was a much more efficient catalyst than acetate, phosphate, or carbonate.

MeSH terms

  • Antioxidants*
  • Aspirin*
  • Catalysis
  • Chemical Phenomena
  • Chemistry
  • Hydrolysis
  • Kinetics
  • Sulfites*


  • Antioxidants
  • Sulfites
  • Aspirin