DNA repair: RAD alert

Curr Biol. 1997 Aug 1;7(8):R492-5. doi: 10.1016/s0960-9822(06)00246-6.

Abstract

Mammalian homologues of two important yeast genes involved in DNA double-strand break repair and recombination, RAD51 and RAD54, have been isolated. Knock-out mutations of the genes in mice reveal both reassuring similarities to, and surprising differences from, the analogous mutant phenotypes in yeast.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Helicases
  • DNA Repair / genetics*
  • DNA Repair Enzymes
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Genes, Fungal
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation
  • Phenotype
  • Rad51 Recombinase
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • RAD51 protein, S cerevisiae
  • RAD51 protein, human
  • Rad51 Recombinase
  • Rad51 protein, mouse
  • RAD54 protein, S cerevisiae
  • DNA Helicases
  • DNA Repair Enzymes