Fatal massive liver steatosis--a clinicopathological case report

Acta Gastroenterol Belg. 1997 Apr-Jun;60(2):180-3.


Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) who presented with rapidly progressive cholestasis and hepatocellular failure is reported. Massive macro- and micro-vesicular hepatic steatosis was diagnosed at autopsy. The authors review the clinico-pathological features associated with this condition, and causal factors possibly implicated in this case are discussed in regard with currently considered pathophysiological mechanisms.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anticonvulsants / adverse effects
  • Demeclocycline / adverse effects
  • Fatal Outcome
  • Fatty Liver, Alcoholic / blood
  • Fatty Liver, Alcoholic / etiology
  • Fatty Liver, Alcoholic / pathology*
  • Female
  • Humans
  • Middle Aged
  • Phenytoin / adverse effects


  • Anti-Bacterial Agents
  • Anticonvulsants
  • Demeclocycline
  • Phenytoin