Serotonin, dopamine, and motor effects in Parkinson's disease

Clin Neuropharmacol. 1997 Aug;20(4):300-10. doi: 10.1097/00002826-199708000-00002.


We review recent reports suggesting that use of selective serotonergic agents that either inhibit synaptic reuptake or have specific serotonin receptor affinities may benefit a variety of motor disturbances in Parkinson's disease. The complex, mixed motoric effects of these agents in Parkinson's disease have not allowed for a consistent view on the interrelationship between dopamine and serotonin (5HT) in motor control but may speak to the nature of dysregulated neurotransmission in the disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dopamine / physiology*
  • Humans
  • Movement Disorders / drug therapy
  • Movement Disorders / physiopathology*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology*
  • Serotonin / physiology*
  • Serotonin Agents / adverse effects
  • Serotonin Agents / therapeutic use


  • Serotonin Agents
  • Serotonin
  • Dopamine